Broad-spectrum antibiotics. A distinction is made between short-term tetracyclines and long-term tetracyclines.
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Tetracyclines
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- 10 h: tetracycline-HCl, oxytetracycline
- Long term tetracyclines (15-18 h): Doxycycline, Minocycline
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Major interactions of tetracyclines.
Alcohol abuse, chronic. |
Tetracycline degradation↑ |
Methoxsalen |
Photosensitization ↑ |
Antacids |
Tetracycline levels↓ |
Antidiabetics, oral |
Blood sugar lowering ↑ |
Anticoagulants, oral |
Bleeding tendency ↑ |
Cephalosporins |
Cephalosporin action ↓ |
Ciclosporin A |
Toxicity of ciclosporin ↑ |
Didanosine |
Tetracycline effect↓ |
Digoxin |
Digoxin plasma levels ↑ |
Enzyme inducers |
Tetracycline degradation↑ |
Ergotamine |
Vasospasm ↑ |
Insulin action ↑ |
|
Contraceptives, oral |
contraceptive effect ↓ |
Lithium salt |
Lithium levels ↑ |
Methotrexate |
Methotrexate toxicity ↑ |
Methoxyflurane |
Renal failure |
Milk and dairy products |
Tetracycline absorption↓ |
Retinoids |
intracranial pressure increase, combination contraindicated |
Theophylline |
Theophylline plasma levels ↑ |
Thiomersal |
Conjunctivitis with use of thiomersal-containing contact lens cleaners. |