Single-strand conformation polymorphism analysis: Screening method for mutations based on the different electrophoretic running behaviour of single-strand DNAs with minimally different nucleotide sequences. For this analysis, the affected DNA region (usually single exons of genes mutated in certain diseases) is first amplified by PCR. After amplification, the double-stranded PCR products are denatured to obtain single strands, which are then examined for their running behavior in a gel electrophoresis. A difference of a single nucleotide leads to an altered conformation of the single strand and to an altered running behaviour in the gel.