The NFKB1 gene (NFKB1 stands for "Nuclear Factor Kappa B Subunit 1") is a protein-coding gene located on chromosome 4q24. Alternative splicing results in several transcript variants that code for different isoforms, at least one of which is proteolytically processed.
The NFKB1 gene encodes a 105 kD protein that can be co-translationally processed by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA-binding subunit of the NF-kappa-B (NFKB) protein complex.
The NFKB1 gene (NFKB1 stands for "Nuclear Factor Kappa B Subunit 1") is a protein-coding gene located on chromosome 4q24. Alternative splicing results in several transcript variants that code for different isoforms, at least one of which is proteolytically processed.