Myositis ossificansM60.8

The term "Myositis proliferans" is used for various, genetically different, clinical pictures, which are characterized by a similar tissue reaction pattern, a heterotopic (extraosseous) ossification. Heterotopic ossification leads to painful, pseudotumorous nodes along the tendons and tendon sheaths as well as within the skeletal muscles. It is severe in familial myositis ossificans, also known as fibrodysplasia ossificans progressive, and leads to severe movement restrictions and early death between the ages of 40 and 50.

Basically 2 forms can be distinguished:

• Sporadic myositis ossificans
  • Circumscripts myositis ossificans (post-traumatic etiology)
  • Idiopathic/pseudomalignant myositis ossificans (non-traumatic etiology)
• Familial myositis ossificans(fibrodysplasia ossificans progressive)

Clinic, histology (see below the respective clinical pictures)

1. Altmeyer P et al (1983) Proliferative Myositis. Dermatologist 34: 221-224
2. Bauer AH et al (2018) Fibrodysplasia ossificans progressiva: a current review of imaging findings. Skeletal radiol 47:1043-1050.
3. Chevalier X et al (1993) Proliferative myositis as a complication of rheumatoid vasculitis. J Rheumatol 20: 1259-1260
4. Kaplan FS et al (2008) Fibrodysplasia ossificans progressiva. Best Pract Res Clin Rheumatol 22: 191-205.
5. Kent MS et al (2002) Proliferative myositis: a rare pseudosarcoma of the chest wall. Ann Thorac Surg 73: 1296-1298
6. Core WH (1960) Proliferative Myositis: a pseudosarcomatous reaction to injury. Arch catholic 69: 209-216
7. Pignolo RJ et al (2013) Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Pediatric Endocrinol Rev 10 Suppl 2:437-48.
8. Turner R et al (1997) Proliferative myositis: an unusual cause of multiple subcutaneous nodules. Clin Exp Dermatol 22: 101-103