Gyrase inhibitors; Gyrase-Hemmer; Fluorchinolone;

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 14.04.2021

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Synonym(s)

Quinolones

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DefinitionThis section has been translated automatically.

Group of antibiotics belonging to the group of quinolones that act by inhibiting bacterial topoisomerase (gyrase) involved in DNA transcription and replication. Belonging to this group are, among others:

Pharmacodynamics (Effect)This section has been translated automatically.

Fluoroquinolones are topisomerase (gyrase) inhibitors with bactericidal activity. They inhibit the two bacterial topoisomerases II (DNA gyrase) and IV. Both enzymes are responsible for the folding and twisting(supercoiling) and the correct packaging of the double-stranded ring-shaped DNA in the bacterial chromosome. They thus ensure the regular course of DNA replication and transcription. Fluoroquinolones belong to the group of concentration-dependent antibiotics.

IndicationThis section has been translated automatically.

Infections, especially from gram-negative germs. Ciprofloxacin has the best activity against Pseudomonas aeruginosa.

Undesirable effectsThis section has been translated automatically.

Gastrointestinal disorders; CNS disorders; exanthema, pruritus; photosensitization.

InteractionsThis section has been translated automatically.

See Table 1.

ContraindicationThis section has been translated automatically.

Pregnancy, lactation, children and adolescents in the growth phase.

TablesThis section has been translated automatically.

Significant interactions of gyrase inhibitors

Antacids, mineral

Absorption of gyrase inhibitors ↓

Anticoagulants, oral

Bleeding tendency ↑

Ciclosporin

Ciclosporin levels ↑

Fenbufen

Seizures ↑

Glibenclamide

Hypoglycemia ↑

Theophylline

Theophylline concentration and effect ↑

Authors

Last updated on: 14.04.2021

Author: Prof. Dr. med. Peter Altmeyer