In the 18th century, the English physician Matthew Dobson was the first to observe a connection between blood and urine glucose.
For a long time, blood glucose measurement was the only method of monitoring blood glucose in diabetes mellitus. Initially, this was done by evaporating the urine, in which sugar crystals and, through yeast, the fermentation of the urine sugar could then be detected. It was not until 1941 that a copper reduction method, the Clinitest, was marketed by the Ames Company (Walker 1990).
The first glucose oxidase-based test (GOD test), the Clinistix, followed in 1956 from Ames Comp. Elkhart (Voswinckel 1993).