Epigenetic autosomal mosaicism

Last updated on: 27.07.2021

Dieser Artikel auf Deutsch

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

The assumption that autosomal mosaics are not hereditary has been refuted: hereditary autosomal epigenetic mosaics have been detected in mice, dogs and other mammals. Since a large number of retrotransposons are also present in the human genome - it is estimated that they account for 42 percent of the genome, although the majority remain inactive - it is assumed that human autosomal mosaics can also be caused by the activity of retrotransposons and thus be inherited.

This would explain why autosomal mosaic states sometimes occur in several family members, as has been observed, for example, in striped pigment disorders or in inflammatory linear verrucous epidermal hamartoma.

Last updated on: 27.07.2021