Endogenous substances that bind to the cannabinoid receptors CB 1 and CB 2, like the externally supplied phytocannabinoids or synthetic cannabinoids. Endocannabinoids include N-arachidonoylethanolamine(anandamide) and 2-arachidonoylglycerol in addition to the aforementioned receptors. The endocannabinoid system regulates numerous physiological and pathological conditions.
The functions of the CB1 receptor include: pain inhibition, appetite increase, anxiety reduction, protection of the brain after injury.
The CB2 receptor in the central and peripheral nervous system, gastrointestinal tract and cells of the immune system has an anti-inflammatory effect.