Zieve syndromeK70.0
HistoryThis section has been translated automatically.
Zieve, 1958
DefinitionThis section has been translated automatically.
Alcohol-induced icterus with pancreatitis, hyperlipidemia (triglycerides and cholesterol) and hemolytic anemia.
EtiopathogenesisThis section has been translated automatically.
Occurs with chronic alcohol consumption and consecutive liver insufficiency.
Bilirubin binds to elastin with increased affinity; jaundice manifests itself first in the sclera (increased elastin content).
Clinical featuresThis section has been translated automatically.
Jaundice of varying severity.
Hardly any skin changes in the hemolytic phase.
As the disease progresses, non-itching (almost asymptomatic), scaly, centrifugally growing, circulatory erythema (probably identical to erythema necroticans migrans).
TherapyThis section has been translated automatically.
Therapy of the underlying disease, regression of the skin change in case of prolonged alcohol withdrawal!
LiteratureThis section has been translated automatically.
- Vogl A et al (2005) Skin and alcohol. J Dtsch Dermatol Ges 3: 788-790
- Zieve L (1958) Jaundice, hyperlipemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann Intern Med 48: 471-496