Vulvovaginitis herpetica recidivansA60
DefinitionThis section has been translated automatically.
Recurrent infection with herpes simplex viruses in the vulva and vaginal area.
TherapyThis section has been translated automatically.
S.u. herpes simplex recidivans and vulvovaginitis herpetica.
- For persistent herpes recurrence 6-12 times/year:
- Prolonged oral Aciclovir therapy: 4 times/day 200 mg Aciclovir (e.g. Zovirax) p.o. for 6-12 months In case of recurrence: dose increase to 5 times/day 200 mg p.o. Dose reductions to 400 mg/day or 200 mg/day can be attempted later.
Children over 2 years receive the adult dose, children under 2 years receive half of the adult dose. In case of resistance to therapy Foscarnet(e.g. Foscavir) 40 mg/kg bw every 8 hours as a 1 hour infusion over 7-10 days depending on the clinic. - Immune stimulation with autologous blood treatments: collection of venous autologous blood with immediate, deep intramuscular injection in increasing amounts (initially 2 ml/week, weekly increase by 2 ml to 10 ml. Injection every 14 days for 3 months).
- Inosine (e.g. isoprinosines) 6-8 times 1 tbl/day p.o.
External therapyThis section has been translated automatically.
In particular in recurrent infections, the external application of interferon alfa has been shown to be successful in some cases .
LiteratureThis section has been translated automatically.
- Corey L et al (2004) Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med 350: 11-20
- Erlich KS et al (1989) Foscarnet therapy for severe acyclovir-resistant herpes simplex type 2 infections in patients with AIDS. Ann Internal Med 110: 710-713
- Kaplowitz LG et al (1991) Prolonged continous acyclovir treatment of normal adults with frequently recurring genital herpes simplex virus infections. JAMA 265: 747-751
- Maccato ML (1992) Herpes genitalis. Dermatol Clin 10: 15-22
- Villa A et al (2003) Genital herpes infection: beyond a clinical diagnosis. Skinmed 2: 108-112