Verrucosis polyneuropathica of the feetE14.4; E14.6
Synonym(s)
verrucous skin lesions of the feet in diabetic polyneuropathy; Verrucous skin lesions on the feet in diabetic neuropathy; VSLDN
HistoryThis section has been translated automatically.
Gerbig and Hunziker, 1995
DefinitionThis section has been translated automatically.
Verrucous, benign epidermis proliferation of the feet, mostly occurring in patients with diabetes mellitus and polyneuropathy, but also in patients with polyneuropathies of other etiologies (e.g. alcohol toxic polyneuropathy).
EtiopathogenesisThis section has been translated automatically.
Unsolved. Discussed are chronic pressure or shear forces in existing neuropathy and angiopathy. Analogous clinical pictures are also observed in alcoholic polyneuropathy.
ManifestationThis section has been translated automatically.
Mainly occurring in old age.
LocalizationThis section has been translated automatically.
Toes and back of the foot.
Clinical featuresThis section has been translated automatically.
Particularly at pressure points, well defined, 2-5 cm large, skin-coloured to brown-blackish, wart-like, verrucous plaques with hyperkeratotic deposits can be found. Moistening is possible, especially with local infections. Occasionally recurrent pyoderma leads to an uncontrollable local infection, so that partial amputations are necessary.
HistologyThis section has been translated automatically.
Pseudoepitheliomatous epidermal hyperplasia with pronounced hypergranulosis and isolated vacuolated keratinocytes. Focal papillomatosis. Ortho- and parahyperkeratosis. Dermis with thin round cell infiltrates. Mostly strong fibrosis.
Differential diagnosisThis section has been translated automatically.
General therapyThis section has been translated automatically.
Subtle adjustment of diabetes mellitus. Clarification of other causes of polyneuropathy and their therapy. Pressure relief. Ablative measures using a sharp curette or scalpel, if necessary after application of keratolytic external agents such as patches containing salicylic acid (guttaplast).
LiteratureThis section has been translated automatically.
- Gerbig AW, Hunziker T (1995) Verrucous skin lesions on the feet in diabetic neuropathy. Br J Dermatol 133: 1011-1012
- Sueki H et al (2004) Association of verrucous skin lesions and skin ulcers on the feet in patients with diabetic neuropathy. Clin Exp Dermatol 29: 247-253