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TrichilemmomaD23.L

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Trichilemmoma desmoplastic; Tricholemmoma

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HistoryThis section has been translated automatically.

French and Headington, 1962

DefinitionThis section has been translated automatically.

Benign epithelial tumor originating from cells of the outer hair root sheath. S.a. Adnexal tumours with hair differentiation.

LocalizationThis section has been translated automatically.

Located in the head area (nose, upper lip, cheeks).

Clinical featuresThis section has been translated automatically.

Solitary, 0.5-3 cm large, skin-coloured, very solid (consistency like wood), on the base usually well movable tumour with predominantly papillomatous or also verrucous surface. S.a. proliferating tricholemmal cyst. Multiple tricholemmomas can be indications of a Cowden's syndrome.

HistologyThis section has been translated automatically.

Sharply delineated tumor clusters localized in the upper dermis, separated by a hyalinized, eosinophilic membrane. Tumor parenchyma consisting of large, glassy-looking, PAS-positive cells with monomorphic nuclei. Few mitoses. Isolated dyskeratoses in the centre of the tumour. At the edge of the tumor strands a palisade position of the nuclei is visible.

Differential diagnosisThis section has been translated automatically.

Verrucae vulgar; basal cell carcinoma.

TherapyThis section has been translated automatically.

Surgical removal in healthy individuals. In case of insufficient surgical removal, danger of local recurrence, see also tricholemic tumor, proliferating.

Note(s)This section has been translated automatically.

The desmoplastic tricholemmoma is considered a histological variant with a prominent proliferation of the connective tissue tumor stroma.

LiteratureThis section has been translated automatically.

  1. Ackermann B et al (1980) Tricholemmoma. At J Dermatopathol 2: 207-224
  2. Headington JT, French AJ (1962) Primary neoplasms of the hair follicle. Arch Dermatol 86: 430-441
  3. Kaddu S et al (2003) Adnexal tumors with hair follicle differentiation. In: Kerl H et al (ed.) Histopathology of the skin. Springer, Berlin Heidelberg New York, S. 667

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer