Testicular damage, primaryQ98.8
Synonym(s)
Hypergonadotropic hypogonadism; Hypogonadism hypergonadotropic; primary testicular dysfunction; Testicular dysfunction primary
DefinitionThis section has been translated automatically.
Primary damage to the germinal epithelium and/or the Leydig's interstitial cells in the testis with compensatory increased secretion of gonadotropins into the serum ( FSH and/or LH); usually accompanied by a reduced testicular size (less than 10 ml volume of a testis) up to infertility.
Occurrence/EpidemiologyThis section has been translated automatically.
By far the most common cause of infertility in men (97-99%)
EtiopathogenesisThis section has been translated automatically.
Most frequently maldescensus testis, Klinefelter syndrome and viral orchitis, e.g. after parotitis epidemica.
TherapyThis section has been translated automatically.
Not possible, possibly in case of testosterone deficiency Substitution: Boys usually receive 50 mg/month i.m. initially Testosterone depot, slow increase over 2 years to about 100 mg every 2 weeks or 200-250 mg/month i.m. in 1 or 2 ED (e.g. Testosterone Depot Jenapharm). The dosage must be adapted to the development.
LiteratureThis section has been translated automatically.
- De Bellis A et al (2001) Male reproductive system. In: Pinchera A (eds) Endocrinology and Metabolism. McGraw-Hill, London, pp. 377-427
- Megarbane A et al (2003) Primary hypergonadotropic hypogonadism, partial alopecia, and mullerian hypoplasia: Report of a second family with additional findings. At J Med Genet 119A: 214-217
- Partsch EM et al (1988) Pathophysiology of primary testicular dysfunctions. dermatologist 39: 708-711