Sertoli cell syndromeE29.85
Synonym(s)
Absence of germ cells; Castillo Syndrome; Del Castillo Syndrome; Germinal cell aplasia; Sertoli cell-only finding; Sertoli Cell Only Syndrome; Sertoli-cells-only finding; Sertoli-cells-only syndromes
HistoryThis section has been translated automatically.
Del Castillo, Trabucco and de la Balze, 1947
DefinitionThis section has been translated automatically.
Primary normo- or hypergonadotropic testicular damage in men with missing germinal epithelium and sterility.
EtiopathogenesisThis section has been translated automatically.
Unclear, congenital or acquired, infectious or toxic cause.
ManifestationThis section has been translated automatically.
Men, mostly 20-40. LJ.
Clinical featuresThis section has been translated automatically.
Inconspicuous male habitus. Azoospermia in ejaculate.
HistologyThis section has been translated automatically.
Missing germinal epithelium and spermiogenesis, Sertoli cells present, Leydig cells present, tubules partially sclerosed. Only in the focal Sertoli cell syndrome are germ cells still present in variable amounts in the tubules.
TherapyThis section has been translated automatically.
In case of complete azoospermia: No fertility can be achieved. In case of Sertoli focal cell syndrome: In case of fertility, sperm vitality test. If there are mature motile sperm cells, in vitro fertilisation can be attempted. Intracytoplasmic sperm injection if intact precursors are present.
LiteratureThis section has been translated automatically.
- Del Castillo EB, Trabucco A, de la Balze A (1947) Syndrome produced by absence of the germinal epithelium without impairment of the Sertoli or Leydig cells. J Clin Endocr 7: 493