Satoyoshi syndromeQ87.8
HistoryThis section has been translated automatically.
Satoyoshi and Yamada, 1967
DefinitionThis section has been translated automatically.
Rare disease of unknown etiology with progressive, intermittent, painful muscle spasms, amenorrhea, skeletal abnormalities, possibly with multiple fractures, malabsorption and (generalized) alopecia.
Occurrence/EpidemiologyThis section has been translated automatically.
Sporadically occurring; most cases have been described in Japan.
ManifestationThis section has been translated automatically.
Occurs in early childhood and is preferred in the female sex.
Clinical featuresThis section has been translated automatically.
- Dermatologically relevant is diffuse alopecia, which can affect the capillitium but also the whole body. Complete healings are described.
- In the foreground of the clinical picture are severe, progressive and painful muscle spasms, which generally manifest themselves in early childhood.
- The clinical picture is further characterized by severe malabsorption with (secondary?) skeletal deformities that lead to disturbances in size growth as well as endocrinological disorders.
Differential diagnosisThis section has been translated automatically.
Dermatomyositis; other collagenoses (the Satoyopshi syndrome is serologically negative! No auto-AK)
TherapyThis section has been translated automatically.
By pediatrician. Muscle cramps seem to improve under medium-high doses of glucocorticoids (prednisolone 60 mg/m2 KO). Therapy of muscle cramps with amytriptiline (25 mg/day).
LiteratureThis section has been translated automatically.
- Cecchin CR et al (2003) Satoyoshi syndrome in a caucasian girl improved with glucocorticoids-A clinical report. At J Med Genet 118A: 52-54
- Haymon M et al (1997) Radiological and orthopedic abnormalities in Satoyoshi syndrome. Pediatric radiol 27: 415-418
- Matsumura T et al (2002) A case of Satoyoshi syndrome complicating marginal gingivitis of the mandible and dislocation of the temporomandibular joint. Rinsho Shinkeigaku 42: 889-891
- Oyama M et al (1999) Satoyoshi syndrome. Arch Dermatol 135: 91-92
- Satoyoshi E, Yamada K (1967) Recurrent muscle spasms of central origin: a report of two cases. Arch Neurol 16: 254-264
- Wisuthsarewong W et al (2001) Satoyoshi syndrome. Pediatric Dermatol 18: 406-410