Rifabutin
DefinitionThis section has been translated automatically.
Tuberculostatics, chemotherapy.
IndicationThis section has been translated automatically.
Tuberculosis, infections by atypical mycobacteria (MAI), prophylaxis of MAI infection in HIV patients with < 200 CD4 cells/μl.
Limited indicationThis section has been translated automatically.
Pregnancy, lactation, children < 14 years, severe liver and kidney failure.
Dosage and method of useThis section has been translated automatically.
Tuberculosis (combination therapy): 150 mg/day p.o., in case of immunosuppression 300 mg/day p.o.
MAI: 300 mg/day p.o. for up to 6 months after achieving negative cultures; in combination with clarithromycin, other macrolides or triazole antifungals 300 mg/day. In combination with indinavir: 150 mg/day p.o.
MAI prophylaxis: 300 mg/day p.o.
Reminder. Patients with soft contact lenses must be informed about the possibility of permanent discolouration of the lenses!
Undesirable effectsThis section has been translated automatically.
Allergic reactions, skin discoloration and discoloration of body excretions after red-orange, headaches, sleep disorders, uveitis, chest pain, anemia, eosinophilia, leukopenia, neutropenia, thrombopenia, abdominal pain, myalgias.
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Rifamycin hypersensitivity, acute hepatitis or cirrhosis of the liver, occlusive scterus, thrombocytopenia.
PreparationsThis section has been translated automatically.
Mycobutin
TablesThis section has been translated automatically.
Major interactions of rifabutin
Quinidine |
Quinidine effect ↓ |
Clarithromycin |
Rifabutin toxicity (plasma levels around 80% ↑, possibly dose reduction). |
Cotrimoxazole |
Cotrimoxazole effect ↓ |
Coumarins |
Coumarin effect ↓ |
Dapsone |
Dapsone effect ↓ |
Didanosine |
Palpitations, tachycardia |
Fluconazole |
Rifabutin levels around 80% ↑, possible dose adjustment. |
Glucocorticoids |
Glucocorticoid effect ↓ |
Cardiac glycosides |
Cardiac glycoside effect ↓ |
Contraceptives, oral |
contraceptive effect ↓ |
L-methadone |
L-methadone effect ↓ |
Opioids |
Opioid effect ↓ |
Phenytoin |
Phenytoin effect ↓ |
Sulfonylurea effect ↓ |