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Radiation recall dermatitisL30.8 + T66
Synonym(s)
DefinitionThis section has been translated automatically.
Local inflammatory reaction of the previously irradiated skin areas after the start of a mostly cytostatic systemic therapy of an underlying tumor.
Occurrence/EpidemiologyThis section has been translated automatically.
The actual incidence of RRD is not known and may depend on several factors, including the radiotherapy dose, the type of systemic therapy, the time between the end of radiotherapy and the administration of systemic therapy, and the dose of systemic therapy (Bhangoo, R. S. et al. 2022).
EtiopathogenesisThis section has been translated automatically.
Despite many case descriptions, the etiology remains unclear. Diverse hypotheses ranging from allergic reactions to degraded epithelial stem cells are propagated.
ManifestationThis section has been translated automatically.
The occurrence of RRD has been described in case reports following the use of chemotherapeutic agents (e.g., actinomycin D (dactinomycin), methotrexate, doxorubicin, gemcitabine, tamoxifen, and bleomycin), as well as antibiotics or tyrosine kinase inhibitors. Disease can occur within days, weeks to years after completion of radiotherapy. Intervals of a few minutes to 14 days have been described with intravenously administered drugs.
LocalizationThis section has been translated automatically.
Clinical featuresThis section has been translated automatically.
Chronic, extensive, usually itchy erythema or reddened plaques confined to a radiation field. Healing with scaling and patchy hypo- or hyperpigmentation. Severe courses with the formation of ulcerations have been described.
HistologyThis section has been translated automatically.
The early phases of the inflammatory reaction are characterized by interface dermatitis and cannot be distinguished from acute radiation dermatitis.
TherapyThis section has been translated automatically.
Note(s)This section has been translated automatically.
Of note is the occurrence of radiation-recall morphea (Spalek M et al. 2015).
Methotrexate can triggerUV recall in a similar manner, although UV irradiation should not have occurred more than 5 days ago
In addition to the skin, other organs may be affected by radiatio-recall reactions (e.g.cardiac organ).
LiteratureThis section has been translated automatically.
- Bhangoo, R. S. et al. (2022). Radiation recall dermatitis: A review of the literature. Semin Oncol 49:152-159.
- Clark E et al. (2015) Chlorambucil-Induced Radiation Recall Dermatitis. Skinmed 13:317-319
- Delavan JA et al. (2015) Gemcitabine-induced radiation recall myositis. Skeletal Radiol 44:451-455.
- Haraldsdottir S et al. (2016) Radiation Recall Dermatitis With Concomitant Dabrafenib and Pazopanib Therapy. JAMA Dermatol 2015.5366
- Kandemir EG et al (2005) Docetaxel-induced radiation recall dermatitis. Swiss med Wkly 135: 35-35
- Kim G et al. (2017) Radiation recall dermatitis triggered by sorafenib after radiation therapy for hepatocellular carcinoma. Radiation oncology journal 35:289-294.
- Prindaville B et al. (2016) Radiation Recall Dermatitis Secondary to Dactinomycin. Pediatr Dermatol 33:e278-279.
- Putnik K et al. (2006) Enhanced radiation sensitivity and radiation recall dermatitis (RRD) after hypericin therapy - case report and review of literature. Radiat Oncol 1: 32-37
- Spalek M et al. (2015) Radiation-induced morphea - a literature review. J Eur Acad Dermatol Venereol 29:197-202.