PinD48.5

Acronym for non-invasive "penile intraepithelial neoplasia" (carcinoma in situ) in the area of the penis (glans penis, inner preputial leaf, penile shaft).

The acronym includes 3 malignant, pre-invasive, epithelial entities of the penis, which are summarized under this term:

• Erythroplasia Queyrat
• fussy M. Bowen
• Bowenoid papulosis.

It is now increasingly common to speak of penile intraepithelial neoplasia.

Most detected cases are HPV infections, with "high-risk-alpha HPV types" dominating HPV 16 and 18. Low-risk HPV types (HPV 6 and 11) are only found in PINs with low dysplasia. Predisposing are HIV infection, genital lichen sclerosus et atrophicus, lichen planus, lack of genital hygiene, smoking.

Pat. with erythroplasia Queyrat and penile M. Bowen are usually affected after the 50th LJ. Patients with bowenoid papulosis usually develop the disease between 28-35 years of age.

Excision of the affected area, electrocausal ablation, laser ablation, topical therapy with 5-FU or Imiquimod.

While erythroplasia and Bowen's disease of the penis almost never show spontaneous remission and in the long run turn into a penis carcinoma, Bowenoid papulosis often shows spontaneous remission with complete healing.