Pemphigoid antibodies

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 05.02.2023

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Synonym(s)

Basement membrane antibody

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DefinitionThis section has been translated automatically.

Antibodies directed against components of the basement membrane, which can be detected by direct immunofluorescence (DIF) in tissue or indirect immunofluorescence (IIF) in serum of patients. The detection of these antibodies (mainly antibodies of the IgG class) is diagnostically groundbreaking in pemphigoid class diseases.

OccurrenceThis section has been translated automatically.

Detectable in about 70% of all patients with bullous pemphigoid, see Table 1.

TablesThis section has been translated automatically.

Disease

Target antigen

Morphological structure

Molecular weight [kDa]

Bullous pemphigoid

BP 180/ BPAG2

Hemidesmosomes/anchoring fibrils

180

BP 230/ BPAG1

Hemidesmosomes

230

Pemphigoid gestationes

BP 180/ BPAG2

Hemidesmosomes/anchoring fibrils

180

BP 230/ BPAG1

Hemidesmosomes

23

Cicatrizing pemphigoid

BP 180/ BPAG2

Hemidesmosomes/anchoring fibrils

180

BP 230/ BPAG1

Hemidesmosomes

230

laminin 5

anchoring fibrils

105, 140, 165

laminin 6

anchoring fibrils/extracellular matrix

165, 200, 220

Integrin ß 4 subunit

Hemidesmosomes

200

IgA linear dermatosis

LAD-1/ LABD97

anchoring filaments

97/120

BP 180/ BPAG2

Hemidesmosomes/anchoring filaments

180

BP230/ BPAG1

Hemidesmosomes

230

Type VII collagen

anchoring filaments

145/290

Anti-p200 pemphigoid

p 200

Adhesion molecule of basement membrane?

200

Epidermolysis bullosa acquisita

Type VII collagen

anchoring filaments

145/290

Bullous systemic lupus erythematosus

Type VII collagen

anchoring filaments

145/290

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Last updated on: 05.02.2023