The MVD gene (MVD stands for mevalonate pyrophosphate decarboxylase) is a protein-coding gene located on chromosome 16q24.2. The encoded protein is an enzyme, mevalonate pyrophosphate decarboxylase. This catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate (IPP). The substrate is decarboxylated and dehydrated with ATP consumption. The mevalonate (MVA) pathway leads to isopentenyl diphosphate (IPP), an important precursor for the biosynthesis of isoprenoids.
Diseases associated with mutations in the MVD gene include porokeratosis 7 (Qian W et al. 2021).