Hypokeratosis, circumscribed acralL98.9

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

circumscribed acral hypokeratosis; circumscribed palmar or plantar hypokeratosis; circumscribed palmoplantar hypokeratosis

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HistoryThis section has been translated automatically.

Pérez, 2002

DefinitionThis section has been translated automatically.

Controversial, apparently congenital, very rare, eminently chronic, solitary epidermal differentiation disorder of the skin with the following clinical characteristics: atrophic, circumscripter (sharply defined, as if punched out), 0.2-3.0 cm large, less symptomatic red spot, which occurs predominantly on the palmar and less frequently on the plantar skin of the groin.

EtiopathogenesisThis section has been translated automatically.

Unexplained; apparently a genetically induced circumscript keratinization defect with consecutive loss of keratinocyte adhesiveness occurs.

ManifestationThis section has been translated automatically.

Women, more rarely older men.

LocalizationThis section has been translated automatically.

Predominantly the ball of the thumb, but also other parts of the palm and, more rarely, the sole of the foot.

Clinical featuresThis section has been translated automatically.

Sharply defined, 0.2-3.0 cm large, solitary, red, slightly sunken spot (atrophy) with an indicated, slightly scaled edge. Occasionally an increased sensitivity to cold is reported.

HistologyThis section has been translated automatically.

Circumscripter, like punched out appearing thinned out orthokeratotic corneal layer. Regular-looking epidermis with a slightly thinned str. granulosum; low superficial, non-specific dermal infiltrate. No cornoid lamella, no cell atypia.

Differential diagnosisThis section has been translated automatically.

Bowen, M : Unusual localization; this diagnosis can be excluded by histological examination; solitary porokeratosis of the acra: Extremely rare finding; to be clarified histologically.

TherapyThis section has been translated automatically.

Harmless clinical picture, a therapy is generally not necessary. Possibly excision in smaller herds.

Progression/forecastThis section has been translated automatically.

Obviously constant over decades.

LiteratureThis section has been translated automatically.

  1. Erkek E et al (2014) Circumscribed acral hypokeratosis: a report of 2 cases and a brief review of the literature. Cutis 93: 97-101
  2. Nguyen JV et al (2013) Dermatopathology diagnosis. Circumscribed acral hypokeratosis. Cutis 91:19-20
  3. Obermoser G, Zelger B (2003) "Multifocal" circumscribed palmar hypokeratosis: malformation or not? J Am Acad Dermatol 49: 1197-1198
  4. Pérez A et al (2002) Circumscribed palmar or plantar hypokeratosis: a distinctive epidermal malformation of the palms and soles. J Am Acad Dermatol 47: 1197
  5. Rutten A et al (2004) Circumscribed acral hypokeratosis. dermatologist 55: 1060-1063

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer