Herpespsis of the newbornsB00.7
Synonym(s)
Herpes-Sepsis of the newborns
DefinitionThis section has been translated automatically.
Severe, generalized initial infection with Herpes simplex virus(in 75% of cases Herpes simplex type 2), in the newborn (see also Herpes neonatorum).
EtiopathogenesisThis section has been translated automatically.
Infection during the passage of the birth canal when the mother is ill. Rarely infection by sick nursing staff.
ManifestationThis section has been translated automatically.
Especially for premature babies.
Clinical featuresThis section has been translated automatically.
Incubation period 3-6 days. Generalized vesicle eruption, aphthous changes in the mucous membranes, high fever, keratoconjunctivitis. Icterus, dyspnoea, swelling of liver and spleen, tendency to bleed, meningismus or meningoencephalitis.
Differential diagnosisThis section has been translated automatically.
Internal therapyThis section has been translated automatically.
Gamma globulins (e.g. beriglobin 0,2-0,5 ml/kg bw/day i.v.). Aciclovir (strictest indication in infancy) 3 times/day as short infusion (dosage: 380 mg/m2 KO/day).
- Ante partum: Gamma globulin injection in the mother (e.g. beriglobin 20 ml i.m.).
- Post partum: Gamma-globulin injection in the child (e.g. pentaglobin 3-5 ml i.v. on three consecutive days).
Progression/forecastThis section has been translated automatically.
In 60% of cases death within the first week, in another 20% permanent disorders.
ProphylaxisThis section has been translated automatically.
Abdominal incisional ligation in case of maternal disease.