Hemosiderotic fibrolipomatous tumorD36.1
Synonym(s)
HistoryThis section has been translated automatically.
Marshall-Taylor C et al. 2000
DefinitionThis section has been translated automatically.
Very rare, locally aggressively growing, postoperatively often recurrent (dignity?), but not metastasizing, mesenchymal tumor whose entity seems not yet consolidated. The demarcation to the "myxoinflammatory fibroblastic sarcoma" with common cytogenetic features is not yet clear
ManifestationThis section has been translated automatically.
Preferably infants, but also occurs in older age. Female persons seem to be more frequently affected.
LocalizationThis section has been translated automatically.
Back of hands and feet, lower extremity, occasionally also in the face.
Clinical featuresThis section has been translated automatically.
Uncharacteristic, 0.1-1.3 cm large (larger lesions also possible), subcutaneously localized, skin-colored or blue-atropical plaque, which may resemble an older hematoma. Nodules form less frequently.
HistologyThis section has been translated automatically.
Colorful image with fascicles of fibroblastically differentiated, CD34-positive spindle cells (negative for smooth muscle actin and desmin) with injected islets of mature adipocytes, hemosiderin-storing macrophages and multinucleated, osteoclast-like giant cells. Mitoses are rare.
TherapyThis section has been translated automatically.
Operatively with sufficient (histologically safe) safety margin.
LiteratureThis section has been translated automatically.
- Browne TJ et al (2006) Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology 48:453-461.
- Hallor KH et al (2009) Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatoryfibroblastic
sarcoma, haemosiderotic fibrolipomatous tumour, and morphologicallysimilar lesions. J path 217:716-727. - Marshall-Taylor C et al(2000) Fibrohistiocytic lipoma: twelve cases of a previously undescribed benign fatty tumor. Ann Diagn Pathol 4:354-360.
- Marshall-Taylor C et al (2000) Hemosiderotic fibrohistiocytic lipomatous lesion: ten cases of a previously undescribed fatty lesion of the foot/ankle. Mod Catholic 13:1192-1199.
- Sawalha S et al (2011) Recurrent haemosiderotic fibrohistiocytic lipomatous lesion of the hand. Malays J Pathol 33:43-45.
- West AT et al (2008) Haemosiderotic fibrohistiocytic lipomatous lesion/tumour of the foot: MRI and histopathology. Skeletal radiol 37:71-74.