Fomepizole
Synonym(s)
4-methylpyrazole; Fomepizole hemisulphate
DefinitionThis section has been translated automatically.
Competitive inhibitor of alcohol dehydrogenase (ADH). Antidote for ethylene glycol poisoning and methanol poisoning.
IndicationThis section has been translated automatically.
Approved in Germany for the treatment of ethylene glycol poisoning. Fomepizole is also suitable for methanol poisoning (not yet approved).
Dosage and method of useThis section has been translated automatically.
Treatment should be started as soon as possible after poisoning and also in suspected cases. Patients with normal kidney function are initially given a continuous intravenous infusion of 15 mg/kg bw in isotonic saline solution or 5% glucose solution (over 30 to 45 minutes). Repeat infusion after 12, 24, 36 hours with 10 mg/kg KG. Infuse 5-15 mg/kg KG after 48 and 60 hours. Use until the plasma concentration of ethylene glycol is below 0.2 g/l. Determine ethylene glycol plasma level every 12-24 hours.
PreparationsThis section has been translated automatically.
FOMEPICOLS OPI
Note(s)This section has been translated automatically.
The antidote can be infused during haemodialysis; its effectiveness is not affected by alcohol.