Fibromatoses (overview)M72.8
Synonym(s)
Fibromatosis; Myofibroblastosis infantile
DefinitionThis section has been translated automatically.
Heterogeneous group of neoplasms of the connective tissue, which nosologically stand between reactive neoplasms and true neoplasias. Nevertheless, they show locally infiltrating and destructive growth but without metastatic tendency. Especially congenital forms and familial occurrence and the detection of mutations (see below fibromatosis, hyaline juvenile) speak for a genetic basis at least for some members of this disease group.
ClassificationThis section has been translated automatically.
The skin, oral mucosa, fascia and musculature (more rarely in internal organs) are differentiated:
- Superficial (superficial) fibromatosis (or Dupuytren's group):
- Dupuytren's contracture (palmar fibromatosis)
- plastic penis induratio
- Plantar fibromatosis
- Knuckle pads real.
- Deep fibromatosis (or desmoid group):
- Desmoid (intraabdominal and extraabdominal [in scars]).
- Infantile fibromatosis:
- Hamartoma, fibrous of childhood
- Myofibromatosis, infantile (fibromatosis, congenital, generalized)
- Fibromatosis gingivae
- Fibromatosis gingivae with hypertrichosis lanuginosa
- Fibromatosis gingivae with fibroadenomatosis mammae
- Fibromatosis, digital infantile
- Fibromatosis, hyaline juvenile (Fibromatosis, infantile aggressive)
- Fibromatosis, infantile, desmoid
- Fibromatosis colli.
Progression/forecastThis section has been translated automatically.
See below the individual clinical pictures.
Note(s)This section has been translated automatically.
Proliferation from fibroblasts and myofibroblasts, which initially have a cell-rich stage, later a cell-poor, fibrous stage.
LiteratureThis section has been translated automatically.
- Burgdorf WHC et al (2003) Benign and malignant tumors. in: Schachner et al. (eds). Pediatric dermatology. Edinburgh, Mosby, S. 863-899
- de Bree E et al (2004) Incidence and treatment of recurrent plantar fibromatosis by surgery and postoperative radiotherapy. On J Surgery 187: 33-38
- Hanks S et al (2003) Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. On J Hum Genet73: 791-800
- Kadwa S (2003) Juvenile aggressive fibromatosis. SADJ 58: 299-302
- Graells Estrada J et al (2003) Familial plantar fibromatosis. Clin Exp Dermatol 28: 669-670
- Ulrich D et al (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytren's disease. Plast Reconstr Surgery 112: 1279-1286