Fibroblastoma desmoplasticD23.-
Synonym(s)
DefinitionThis section has been translated automatically.
Rare, mostly extensive, benign, predominantly subcutaneous, more rarely cutaneously localized, fibroplastic tumor, which occurs mainly in adult male patients.
LocalizationThis section has been translated automatically.
Back, upper and lower extremities, also head and neck area (oral area, orbit)
Clinical featuresThis section has been translated automatically.
Slowly growing, deep-seated, usually large-volume, plate-like or nodular tumour masses, which, depending on their location, disturb local functions.
HistologyThis section has been translated automatically.
Cell-poor, easily delimitable tumour of fibroblastically differentiated cells in a collagen-rich stroma. No increased proliferative activity. No cell atypia. Tumor cells express vimentin and alpha smooth muscle actin, but not desmin, CD34 and S-100 protein. A translocalization t(2;11) (q31;q12) could be detected in the tumor cells (Nishio J et al.).
TherapyThis section has been translated automatically.
Operational restructuring
LiteratureThis section has been translated automatically.
- Bhagalia S et al (2012) Collagenous fibroma (desmoplastic fibroblastoma) of the oral cavity. J Oral Maxillofac Pathol 16: 277-279.
- Hu SC et al (2015) Dermal desmoplastic fibroblastoma presenting as a large sacral mass. Australas J Dermatol doi: 10.1111/ajd.12363.
- Kawaguchi Y et al. (2015) Invasive desmoplastic fibroblastoma in the chest wall. Ann Thorac Surg 99:e85-86.
- Kim JH et al (2012) Desmoplastic fibroblastoma of the finger tip in an adult. Arch Plast Surg 39: 84-86.
- Nishio J et al (2011) Translocation t(2;11) is characteristic of collagenous fibroma (desmoplastic fibroblastoma). Cancer gene 204:569-571.
- Stacy RC et al (2013) Collagenous fibroma (desmoplastic fibroblastoma) of the orbital rim. Ophthal Plast Reconstr Surg 29:e101-104.