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Epidermal cyst, proliferating L72.0

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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History This section has been translated automatically.

Sau, Graham and Helwig, 1995

Definition This section has been translated automatically.

Slowly growing, skin-coloured tumour corresponding to the proliferating tricholemic cyst, located deep dermally, with epidermal keratinisation of the cyst wall (clearly visible keratohyalin granules in the stratum granulosum).

Etiopathogenesis This section has been translated automatically.

Not clear.

Manifestation This section has been translated automatically.

Men are more frequently affected than women.

Localization This section has been translated automatically.

Capillitium (about 20%), anogenital (30-40%), extremities (10-20%), buttocks, trunk (10-15%).

Clinic This section has been translated automatically.

Rare, solitary or multiple, slowly growing, skin-coloured, 0.4-15 cm large, solid or cystic nodule.

Histology This section has been translated automatically.

Predominantly subepidermally located cystic tumor with central horny masses. Broad wall epithelium keratinizing over a stratum corneum, infiltrating the surrounding tissue in clumsy, ripe cell proliferations. Detection of onion skin-like epithelial rosettes. Increasing cell and nuclear polymorphism and numerous mitoses indicate transition to squamous cell carcinoma.

Complication(s)(associated diseases This section has been translated automatically.

Recurrence after surgical removal in over 20% of cases; risk of carcinomatous degeneration.

Therapy This section has been translated automatically.

Surgical removal with careful margin control.

Aftercare This section has been translated automatically.

Subtle clinical follow-up as in spinocellular carcinoma.

Note(s) This section has been translated automatically.

Apart from the primary publication, which lists 33 cases, the follow-up literature is sparse. Its independence as an entity appears questionable and requires further confirmation.

Literature This section has been translated automatically.

  1. Cameron DS et al (2003) Squamous cell carcinoma in an epidermal inclusion cyst: case report. Otolaryngol Head Neck Surgery 129: 141-143
  2. Debaize S et al (2002) Squamous cell carcinoma arising in a giant epidermal cyst: a case report. Acta Chir Belg 102: 196-198
  3. Folpe AL et al (2003) Proliferating trichilemmal tumors: clinicopathologic evaluation is a guide to biological behavior. J Cutan Pathol 30: 492-498
  4. Perwein E et al (1986) Proliferating epidermal cyst. Dermatologist 37: 102-106
  5. Riemann H et al (1999) Proliferating trichilemmal cyst with focal segments of metastatic squamous epithelial carcinoma. dermatologist 50: 42-46
  6. Sau P, Graham JH, Helwig EB (1995) Proliferating epithelial cysts. Clinicopathological analysis of 96 cases. J Cutan Pathol 22: 394-406

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Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer