Dermicidin

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Antimicrobial peptide. Is released in the eccrine sweat glands of the skin.

General informationThis section has been translated automatically.

  • As a precursor protein, dermicidin is first proteolytically cleaved to form active, antimicrobial derivatives (e.g. DCD-1). The concentration in sweat is about 1-10 μg/ml. These already have a toxic effect on microorganisms.
  • DCD-1 showed in vitro sensitivity to Staph. aureus, E. coli, E. faecalis and Candida albicans.
  • It is constitutively secreted via eccrine sweat glands and spreads with the sweat over the entire skin.
  • Remains stable in the acid mantle of the skin.
  • Excessive and too frequent washing probably has a negative effect on the distribution of dermicidin.
  • Patients with atopic dermatitis have a reduced dermcidin content in their sweat.

LiteratureThis section has been translated automatically.

  1. Rieg S et al (2006) Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J Invest Dermatol 126: 354-365

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer