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Cutaneous mycobacterium spindle cell pseudotumor

Last updated on: 23.03.2023

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HistoryThis section has been translated automatically.

Mycobacterial spindle cell pseudotumor was first described by C. Wood in 1985. The histologic pattern resembled the histoid variant of lepromatous leprosy, so Wood published it as the "histoid" pseudotumoral variant of M. avium complex. Over time, this pattern of mycobacterial infection in various organs has been documented more frequently and termed "mycobacterial spindle cell pseudotumor" (Yeh I et al. 2011).

DefinitionThis section has been translated automatically.

Mycobacterial spindle cell pseudotumor of the skin is a rare, benign (pseudomalign) granulomatous neoplasm characterized in immunocompromised individuals by proliferation of spindle-shaped histiocytes with granulomatous formation in which acid-fast bacteria are detectable. The nodular lesions occur primarily in the skin and lymph nodes, but are also found in other organs (e.g., lungs).

EtiopathogenesisThis section has been translated automatically.

It is suggested that these lesions may occur due to decreased interferon-γ production by CD4+ T-cell lymphocytes.

ManifestationThis section has been translated automatically.

Mycobacterial spindle cell pseudotumor has been described mostly in middle-aged men (Fonda-Pascual P et al 2018).

Differential diagnosisThis section has been translated automatically.

Dermatofibroma, myofibroblastic tumor , nodular fasciitis.

TherapyThis section has been translated automatically.

Excursion

Note(s)This section has been translated automatically.

s. March 2023 Newsletter

LiteratureThis section has been translated automatically.

  1. Coelho R et al. (2017) Mycobacterium genavense-induced spindle cell pseudotumor in a pediatric hematopoietic stem cell transplant recipient: Case report and review of the literature. Transpl Infect Dis. 19(2).
  2. Fonda-Pascual P et al (2018) Penile Mycobacterium avium complex spindle cell pseudotumor. Indian J Dermatol Venereol Leprol. 84:199-202.
  3. Furlan K et al (2020) Mycobacterium Spindle Cell Pseudotumor Caused by Mycobacterium xenopi: A First Described Association of a Rare Entity Presenting in the Lung. Int J Surg Pathol 28:316-320.
  4. Wood C et al (1985) Pseudotumor resulting from atypical mycobacterial infection: A "histoid" variety of Mycobacterium avium-intracellulare complex infection. Am J Clin Pathol 83:524-527.
  5. Yeh I et al (2011) Cutaneous mycobacterial spindle cell pseudotumor: A potential mimic of soft tissue neoplasms. Am J Dermatopathol 33:e66-9.

Last updated on: 23.03.2023