Markers for: thymocytes, Langerhans cells, interdigitating cells, B cell subtypes, dendritic cells, cortical thymocytes, thymomas, T cell lymphomas, lymphoblasts.
Structure: Membrane glycoprotein (49 kDa)
Application: FACS, IHC (P) (G), IF
Cd1a
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
CD1a is an antigen that is mainly expressed on the surface of dendritic cells and Langerhans cells. It plays a role in the presentation of lipid- and glycolipid-based antigens to T cells, particularly to CD1-restricted T cells.
CD1a-positive dendritic cells (DCs) may play a role in antigen presentation during infection with Leishmania species, particularly in the initiation of the T cell response. Some studies have shown that CD1a-expressing cells may be increased in skin biopsies from patients with cutaneous leishmaniasis.
Note: Activation of CD1a-restricted T cells may contribute to the control of Leishmania infections, particularly through the presentation of Leishmania-associated lipid antigens. There is evidence that impaired or altered expression of CD1a in the skin may correlate with the course and severity of cutaneous leishmaniasis (Lopez-Trujillo E et al. 2021).
LiteratureThis section has been translated automatically.
- Hantschke M et al. (2016) Immunohistologic techniques. In: L. Cerroni et al. Histopathology of the skin. Springer Verlag Berlin-Heidelberg pp. 26-33.
- Lopez-Trujillo E et al. (2021)* Diagnostic usefulness of immunohistochemical evaluation of CD1a antigen and polyclonal anti-leishmania antibodies in cutaneous leishmaniasis. Histol Histopathol 36:567-576.