Betamethasone valerate

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 24.04.2021

Dieser Artikel auf Deutsch

Synonym(s)

betamethasone 17-valerate; Betamethasone V

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

Halogenated glucocorticoid. The only betamethasone derivative that is used in magistral formulations as a medium-strength (class II) glucocorticoid in a 0.05% concentration and as a strong (class III) external glucocorticoid in a 0.1% concentration! Betamethasoen-17-valerate has a pH-stability optimum at pH 3.5. In the strongly acidic as well as in the neutral or alkaline range the molecule undergoes a so-called isomerization. The valerate residue moves from the C-17 atom to the C-21 atom. This causes the glucocorticoid to lose about 85% of its effectiveness. For this reason the NRF uses a citrate buffer (pH 4.2) for stabilization in the"hydrophilic betamethasone valerate cream (NRF 11.37.) and in the hydrophilic betamethasone valerate emulsion.

IndicationThis section has been translated automatically.

Eczema, allergic skin reactions, in persistent cases also short-term as interval or tandem therapy for psoriasis vulgaris.

Notice! Application duration max. 4 weeks!

Limited indicationThis section has been translated automatically.

Long-term therapy for children and the face.

Dosage and method of useThis section has been translated automatically.

Apply thinly 1-2 times/day to the affected skin areas.

Standard concentrationThis section has been translated automatically.

0.05-0.1% as cream, ointment, lotion, solution.

ContraindicationThis section has been translated automatically.

Infants < 12 months, pruritus anogenitalis, acne.

Recipe(s)This section has been translated automatically.

  • Betamethasone valerate emulsion, hydrophilic (NRF 11.47.)
  • Betamethasone valeratecream, hydrophilic (NRF 11.37.)
  • Betamethasonevalerate cream (0.05-0.1% W/0)
  • A 0.1% hydrophilic betamethasone valerate emulsion can be combined with 5-10% urea. To prevent degradation of the urea into its parent substances in this emulsion, the addition of a lactate buffer (1% lactic acid and 4% sodium lactate solution) is recommended.
  • Rp
    • Urea pura 10.0 g
    • Acid lact 2,0 g
    • Sodium lact 50% 8.0 g
    • Betamethasone valerate emul. 0.1% NRF 11.47. ad 200.0 g

S.: 01% betamethasone valerate - 10% urea emulsion; expiry date 6 months (plastic bottle)

PreparationsThis section has been translated automatically.

Betnesol-V, Beta-Wolff, Betagalen, Celestan-V, Cordes Beta, Linola Beta, Fucicort (combination with fusidic acid)

LiteratureThis section has been translated automatically.

Wolf g (2012) Inhomogeneities in individual formulations. dermatologist 63: 518-519

Authors

Last updated on: 24.04.2021

Author: Prof. Dr. med. Peter Altmeyer