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Azelaic acid

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 18.05.2021

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Synonym(s)

1,7-heptanedicarboxylic acid; acelaic acid (e); CAS No:123-99-9; Nonanedioic acid

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DefinitionThis section has been translated automatically.

Belonging to the keratolytics, saturated dicarboxylic acid produced by microorganisms. Naturally in rancid oil. Its salts and esters are called azelates. Azelaic acid has anti-inflammatory, antibacterial and anticomedogenic potency. Due to its good local tolerance it allows a long-term therapy of acne.

IndicationThis section has been translated automatically.

Acne comedonica and acne papulopustulosa, acne in adult women, hyperpigmentation,(Chloasma, Lentigines), rosacea

Standard concentrationThis section has been translated automatically.

Apply 15-20% in creams, ointments or gels 2 times/day thinly to the affected areas.

Undesirable effectsThis section has been translated automatically.

Azelaic acid can cause local skin irritation (especially at the beginning of treatment). Furthermore: hypopigmentation (especially in skin type III and IV), hypertrichosis, contact dermatitis, exacerbation of herpes labialis, phototoxic reactions.

ContraindicationThis section has been translated automatically.

Use around the eyes, nose and lips.

PreparationsThis section has been translated automatically.

Skinoren Cream®; Finacea Gel®

LiteratureThis section has been translated automatically.

  1. Gamble R et al (2012) Topical antimicrobial treatment of acne vulgaris: an evidence-based review. At J Clin Dermatol 13:141-152.
  2. Leccia MT et al.(2015) Topical acne treatments in Europe and the issue of antimicrobial resistance. J Eur Acad Dermatol Venereol 29:1485-1492.
  3. Rademaker M (2016)Very low-dose isotretinoin in mild to moderate papulopustular rosacea; a retrospective review of 52 patients. Australas J Dermatol doi: 10.1111/ajd.12522.
  4. Schulte BC et al(2015) Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application. J Drugs Dermatol 14:964-968.
  5. Sieber MA et al (2014) Azelaic acid: Properties and mode of action. Skin Pharmacol Physiol 27 Suppl 1:9-17.
  6. Yin NC et al (2014) Acne in patients with skin of color: practical management. At J Clin Dermatol 15:7-16.

Authors

Last updated on: 18.05.2021

Author: Prof. Dr. med. Peter Altmeyer