Atovaquone/proguanil
DefinitionThis section has been translated automatically.
Spectrum of actionThis section has been translated automatically.
Effective against blood and hepatic schizons of P. falciparum (Malaria tropica).
IndicationThis section has been translated automatically.
Prophylaxis of malaria tropica and treatment of acute, uncomplicated malaria tropica, especially if P. falciparum may be resistant to other antimalarial drugs.
Pregnancy/nursing periodThis section has been translated automatically.
Strict indication (insufficient data available).
Dosage and method of useThis section has been translated automatically.
Malarone (250 mg atovaquone/100 mg proguanil per tbl.):
- Adults, children > 40 kg bw: 4 film bl. as ED on 3 consecutive days.
- Children: 11-20 kg bw: 1 tbl./day each for 3 consecutive days; 21-30 kg bw: 2 tbl. each as ED for 3 consecutive days; 31-40 kg bw: 3 tbl. each as ED for 3 consecutive days.
Prophylaxis: 1 tablet p.o. 1 time/day 1-2 days before entering endemic area, continue during stay and 7 days after leaving endemic area.
Reminder. If vomiting occurs as a side effect after taking the medication, the dose should be taken again (especially for malaria prophylaxis)!
Undesirable effectsThis section has been translated automatically.
Occasional headache, abdominal pain, diarrhea, fever, nausea, vomiting, pruritus.
InteractionsThis section has been translated automatically.
Reduction of atovaquone plasma levels with simultaneous treatment with metoclopramide, tetracyline, rifampicin, rifabutin.
ContraindicationThis section has been translated automatically.
Malaria prophylaxis in patients with severely impaired kidney function (creatinine clearance < 30 ml/min).
PreparationsThis section has been translated automatically.
Malarone, Malarone Junior