Amoxicillin/clavulanic acid
DefinitionThis section has been translated automatically.
Combination preparation of the β lactamase inhibitor clavulanic acid with amoxicillin.
Half-lifeThis section has been translated automatically.
1 h
IndicationThis section has been translated automatically.
Infections by amoxicillin-sensitive and resistant pathogens, if the resistance is based on the formation of β lactamases.
Limited indicationThis section has been translated automatically.
Pregnancy, nursing.
Dosage and method of useThis section has been translated automatically.
- 3.6-6.6 g/day i.v. in 3 ED or 1.8-3.6 g/day p.o. in 3 ED
- Children: 60 mg/kg bw/day i.v. in 3 cycles or 37.5-75 mg/kg bw/day p.o. in 3 cycles.
Undesirable effectsThis section has been translated automatically.
S.u. Amoxicillin.
InteractionsThis section has been translated automatically.
S.u. Benzylpenicillin. Decreasing the effect of aminoglycosides and increasing the side effects of disulfiram.
ContraindicationThis section has been translated automatically.
Penicillin allergy, infectious mononucleosis and other viral infections (increased risk of exanthema!), leukemias.
Remember! Amoxicillin/clavulanic acid is contraindicated in patients who have already had liver dysfunction during previous therapy.
PreparationsThis section has been translated automatically.
Augmentan
Note(s)This section has been translated automatically.
The use of amoxicillin/clauvlanic acid in patients with pre-existing liver dysfunction and in elderly patients over 60 years of age should be used with great caution due to the risk of possible side effects. A regular laboratory check of the liver values is recommended. Relatively high rate of exanthema in the whole group (also in combination with ß-lactamase inhibitor).
LiteratureThis section has been translated automatically.
- Larrey D et al (1992)Hepatitis associated with amoxycillin-clavulanic acid combination report of 15 cases. Well 33: 368-371.