Penicillin g

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

Benzylpenicillin

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

Benzylpenicillin, a batalactam antibiotic with the molecular formula C16H18N2O4S, is a bactericidal antibiotic(penicillin) that acts on proliferating Gram-positive bacteria. Benzylpenicillin is acid-labile and can therefore only be applied parenterally. Drugs with this active ingredient are injected intramuscularly or intravenously. The sodium and potassium salts of penicillin G act quickly, but are also rapidly eliminated. Depotpenicillin (e.g. benzyl-penicillin-procaine = procaine-penicillin G) is a white powder which is poorly soluble in water and guarantees a long period of effectiveness.

Half-lifeThis section has been translated automatically.

0,6–1 h

Pharmacodynamics (Effect)This section has been translated automatically.

Benzylpenicillin belongs to the group of active ingredients of betalactam antibiotics and is effective against a variety of pathogens, including various streptococci, non-penicillinase-forming staphylococci, pneumococci and meningococci. Benzylpenicillin acts by preventing internal cross-linking during the rebuilding of the bacterial cell wall (see below penicillins). The cell wall is weakened and perishes.

Benzylpenicillin is not effective against Gram-negative bacteria, with the exception of Gram-negative cocci. These bacteria have a further coating over the actual cell membrane. This makes it impossible for benzylpenicillin to access the cell membrane.

Benzylpenicillin is the classic example of the development of antibiotic resistance (development of resistance in gonococcal strains).

Spectrum of actionThis section has been translated automatically.

Actinomycetes, Bacillus anthracis, Borrelia, Clostridium perfringens, Diphtheria bacteria, Erysopelothrix rhusiopathiae, Gonococci, Leptospires, Meningococci, Pasteurella, Group A and B Streptococci, Str. viridans, Anaerobic streptococci, Treponemes.

IndicationThis section has been translated automatically.

Angina, pharyngitis, meningitis, lobar pneumonia, erysipelas, erysipeloid, borreliosis, leptospirosis, syphilis, actinomycosis, diphtheria, clostridial myonecrosis ( gas fire), tetanus, lichen sclerosus et atrophicus, circumscribed scleroderma.

Dosage and method of useThis section has been translated automatically.

Adults: 1-30 million IU/day in 4-6 weeks.Infants: 0.04-0.5 million IU/kg bw/day in 4-6 weeks.Infants: 0.2-1 million IU/kg bw/day in 4-6 weeks.Newborns: 0.075-0.2 million IU/kg bw/day in 3 weeks.

PreparationsThis section has been translated automatically.

Benzylpenicillin potassium (CAS 113-98-4), Benzylpenicillin sodium (CAS 69-57-8), Benzylpenicillin procaine 1 water (CAS 6130-64-9), Clemizol penicillin (CAS 6011-39-8), Benzylpenicillin benzathine (CAS 1538-09-6), Benzylpenicillin benzathine 4 water (CAS 41372-02-5)

Commercial preparations:

INFECTOCILLIN® parenteral 1 Mega, 1 million I.U., powder for solution for injection or infusion; InfectoPharm Arzneimittel u. Consilium GmbH

INFECTOCILLIN® parenteral 5 Mega, 5 million I.U., powder for solution for injection or infusion, DSF InfectoPharm Arzneimittel and Consilium GmbH

INFECTOCILLIN® parenteral 10 Mega, 10 million I.U./100 ml, powder for the preparation of an injection or infusion solution, InfectoPharm Arzneimittel u. Consilium GmbH,

Penicillin G INFECTOPHARM® 1 Mega, powder for solution for injection or infusion InfectoPharm Arzneimittel u. Consilium GmbH

Note(s)This section has been translated automatically.

With proven sensitivity, penicillin V has a 10 to 100 times stronger effect against staphylococci than staphylococci penicillins.

LiteratureThis section has been translated automatically.

  1. Wright GD (2007) Biochemistry. A new target for antibiotic development. Science 315: 1373-1374

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer