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Widal, morbusJ45.1
Synonym(s)
HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Clinical syndrome with the following triad (velvet triad):
- ASA intolerance (see intolerance reaction below;see drug intolerance, analgesia-induced)
- nasal polyps
- Bronchial asthma.
However, this clinical entity is not limited to ASA. It is also observed in the use of other non-steroidal anti-inflammatory drugs. Patients with Widal's syndrome have a significantly increased tendency to relapse with standard sinusitis therapy.
Occurrence/EpidemiologyThis section has been translated automatically.
AERD (aspirin-exacerbated respiratory disease) can be detected in about 10% of asthmatics.
EtiopathogenesisThis section has been translated automatically.
According to current knowledge, the reaction is not based on an IgE-mediated mechanism. The cause is a dysbalance in the arachidonic acid metabolism (increased leukotriene production), which is increased by the intake of non-steroidal anti-inflammatory drugs or salicylates in the diet.
A mutation in the C444 allele of leukotriene C synthase has been described as a possible cause.
TherapyThis section has been translated automatically.
Internal therapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- May A et al (2000) Family investigation in patients with ASA intolerance and rhinosinusitis. HNO 48: 650-654
- Widal MF, Abramin P, Lermoyez J (1922) Anaphylaxis and idiosyncrasy. Press Med 30: 189