Pneumonia, eosinophilic chronic J18.9

Chronic eosinophilic pneumonia is a rare, aetiologically unexplained disease associated with blood eosinophilia (in 80% of cases) as well as systemic symptoms such as fever, chills, night sweats, cough, loss of appetite and weight loss.

w:m=2:1

Often associated with allergic diathesis. Almost 50% of patients are preceded by bronchial asthma < 5 years.

Chronic eosinophilic pneumonia (CEP) usually begins insidiously with systemic symptoms such as fever, chills, night sweats, cough, loss of appetite and weight loss. About 30% of patients suffer from bronchial asthma at the same time.

Thoracic radiographs often show peripheral (migrating) infiltrates.

Blood eosinophilia (80%), significant IgE increase, p-ANCA positivity (50%).

Clinical picture, chest x-ray, BAL with >40% eosinophilia .

High-dose systemic glucocorticoids

Very short-term and significant improvement of symptoms (within 48h) after the start of glucocorticoid therapy.

1. Sriratanaviriyakul N et al (2016) Chronic eosinophilic pneumonia presenting with ipsilateral pleural effusion: a case report. J Med Case Rep 10:227.
2. Hirai J et al (2017) Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions anda
   review of the literature. J Infect Chemother 23:245-249.
3. Kim NH et al (2015) Bronchial involvement in chronic eosinophilic pneumonia: a case report. J Thorac Dis 7: E97-E101
4. Jaimes-Hernández J et al (2012) Chronic eosinophilic pneumonia: autoimmune phenomenon or immunoallergic disease? Case report and literature review. Reumatol Clin 8:145148.

5. Shin YS et al. (2012)Successful treatment of chronic eosinophilic pneumonia with anti-IgE therapy. J Korean Med Sci 27:1261-1264.