Carrot allergyL27.-, L23.6
Synonym(s)
DefinitionThis section has been translated automatically.
Allergic reaction to ingestion of carrot-containing foods. It was observed in the majority of patients with pre-acquired sensitization to birch and mugwort pollen. About 50% of patients develop a systemic reaction.
ClassificationThis section has been translated automatically.
Identified and accepted allergens of Daucus carota (Carrot)
- Dau c 1 pathogenesis-related protein, PR 10 protein
- Dau c 4 profilin
- Dau c 5 Isoflavone reductase-like protein
Occurrence/EpidemiologyThis section has been translated automatically.
Relatively common food allergy (about 10% of all food allergies); third most common allergen in triggering systemic reactions; also as a trigger for oral allergy syndrome. Occupational rhinorrhoea, allergic asthma and contact urticaria are known. Asthmatic complaints can already occur when processing raw carrots.
EtiopathogenesisThis section has been translated automatically.
As allergens Dau c 1 (16-18 kDa), a protein homologous to Bet v 1 ( birch allergen), Dau c 4 a carrot profilin (12 kDa) and an isoflavone reductase-like protein (Dau c 5) were identified. The latter is also found as Bet v 6 (35 kDa) in birch pollen. A cyclin has been identified as a further allergen.
Carrot allergens are heat labile.
Cross-reactions are therefore frequently found with birch pollen in the context of a pollen-associated food allergy and celery(celery-carrot-mugwort spice syndrome).
An isolated carrot allergy without a corresponding pollen depilation is extremely rare!
DiagnosisThis section has been translated automatically.
The sensitivity of an extract-based allergy test is about 80%. Dau c 1 (2 isoforems) are defined as major allergens in addition to the profilin Dau c 4.
LiteratureThis section has been translated automatically.
- Ballmer-Weber BK et al (2012) Component-resolved in vitro diagnosis of carrot allergy in three different regions of Europe. Allergy 67:758-766.
- Ballmer-Weber et al (2007) Carrot allergy: double-blinded, placebo-controlled food challenge and identification of allergens. J Allergy Clin Immunol 108: 301-307
- Fernándes-Rivas et al (2004) Anaphylaxis to raw carrot not linked to pollen allergy. Allergy 59: 1239-1240
- Kawai M et al (2014) Allergic contact dermatitis due to carrots. J Dermatol 41:753-754.
- Morena-Ancillo et al. (2006) Role of Dau c 1 in three different patterns of carrot-induced asthma. Allergol Immunopathol 34: 116-120
- Paulsen E et al (2014) Systemic allergic dermatitis caused by Apiaceae root vegetables. Contact dermatitis. 70: 98-103.
- Wangorsch A et al. (20129 Identification of a Dau c PRPlike protein (Dau c 1.03) as a new allergenic isoform in carrots (cultivar rodelica). Clin Exp Allergy 42:156-166.