Thrombin-activated fibrinolysis inhibitor

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

TAFI

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DefinitionThis section has been translated automatically.

This factor antagonizes fibrinolysis by stabilizing fibrin induced by the thrombin-thrombomodulin complex. It is a carboxylase that cleaves off lysine and arginine residues at the fibrin and thus inhibits the binding of the plasma to the fibrin.

In 2006, a mutation of TAFI was described which has a half-life 180 times longer than that of normal TAFI and thus shows a significantly increased antifibrinolytic effect.

LiteratureThis section has been translated automatically.

  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 113.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer