Protein c deficiency (acquired)D68.5
Synonym(s)
Acquired protein C deficiency; Protein C deficiency
DefinitionThis section has been translated automatically.
Acquired deficiency or lack of protein C.
ClassificationThis section has been translated automatically.
In addition to congenital protein C deficiencies, there are also a number of exogenously caused protein C deficiencies:
- Coumarin therapy
- Asparaginase therapy in the context of leukemia treatment
- in liver diseases, e.g. Budd-Chiari syndrome or venooclusive syndrome (VOD)
- for consumption coagulopathy
- after operations following polytrauma
- for progressive renal insufficiency
- for vitamin K deficiency
- in sepsis
- post-infectious (cloinical) symptoms 10-14 days after the first infection infections (e.g. varicella)
- with massive blood loss
- for chronic inflammatory bowel disease.
The protein C concentration can be increased in:
- pregnancy
- ingestion of ovulation inhibitors
- diabetes mellitus
- Nephrotic syndrome.
EtiopathogenesisThis section has been translated automatically.
Together with a coenzyme, protein S, the protein C/protein S system is activated via the thrombin-thrombomodulin complex in a negative feedback reaction and inhibits the activated factors V and VIII (Va, VIIIa) by proteolytic cleavage. Thus, the protein C/protein S system plays a key role in the inhibition of hemostasis, because with this action it controls the activation of factor X to Xa and thus of prothrombin to thrombin.
LiteratureThis section has been translated automatically.
- HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin S. 219f.