Nitricergic neurons

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Neurons that are able to express neuronal NO synthase (nNOS, neuronal nitrogen monoxide synthase) The neuronal NO synthase (nNOS) in turn is a soluble enzyme that is constitutively expressed in nitrergic nerve cells. Thus, a neurogenic action potential arriving at a nerve ending leads via the Ca2+- influx to the activation of the NO synthase and thus to the formation of NO.

General informationThis section has been translated automatically.

Nitric oxide (NO) is a highly diffusible, short-lived, endogenously formed bioactive molecule. It is found in neurons as well as in endothelial and immune cells, where it acts as a neuromodulator or messenger. Nitric oxide is formed by catalysis of the enzyme nitrogen monoxide synthase (NOS). The NOS (NO synthase) catalyses the reaction of L-arginine to nitrogen monoxide and LCitrulline.

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Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer