Heparin cofactor ii deficiencyD68.5

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Hereditary deficiency, which is found in about 1% of patients who have undergone thrombosis. Due to the lack of heparin cofactor II, thrombin is less inhibited when antithrombin III is strongly decreased. This results in an increased thrombin effect and thus in an increased tendency to thrombosis.

LiteratureThis section has been translated automatically.

  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin S. 230.
  2. Saito A (2015) Heparin cofactor II is degraded by heparan sulfate and dextran sulfate
    . Biochem Biophys Res Commun 457:585-588.

  3. Wood JP et al (2016) Blocking inhibition of prothrombinase by tissue factor pathway inhibitor alpha: a procoagulant property of heparins. Br J Haematol doi: 10.1111/bjh.14182.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer