Factor xiiia

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Fibrin stabilizing factor; Laki Lorand Factor

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DefinitionThis section has been translated automatically.

Factor XIII a is an enzyme and as a coagulation factor it is an important part of the blood coagulation cascade. Factor XIIIa consists of 2x 2 subunits, 2x A and 2x B. Physiological concentration in blood plasma: 10 μg/ml; half-life 5-9 days.

The subunits A and B of factor XIII are encoded by two different genes:

For A: gene 6p25-p24; for B: gene 1q31-q32.1

Immunohistochemically, factor XIIIa reacts with fibrocytes, e.g. in dermatofibromas and the fibrous nasal papule. Dermatofbrosarcoma protuberans reacts CD34+ but negatively for factor XIIIa.

LiteratureThis section has been translated automatically.

  1. West KL et al (2014) Immunohistochemical markers in fibrohistiocytic lesions: factor XIIIa, CD34, S-100 and p75. At J Dermatopathol 36:414-419

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer