Rhodiolae roseae radix

Rhodiolae roseae radix, the root of the rose root, is a drug that is used in herbal medicinal products for stress and for the general improvement of physical and mental performance, among other things.

A pharmacopoeia quality description is not available.

HMPC monograph: Traditional-use: internal: mild stress symptoms, states of exhaustion, feeling of weakness
ESCOP: not processed.
Commission E: not processed.

Empirical medicine: enhancement of physical and mental performance, cognitive vitality: attention, concentration, memory, support of concentration in hyperactive children (see contraindication < 18 years)

Rhodiolae roseae radix contains phenylpropanoids such as rosin, rosarin, rosavin (total content of rosavins according to the HMPC monograph: 0.5-3.0%). In addition, phenylcabonic acids, flavonoids (rhodiolin), phenylthanoids (e.g. p-tyrosol), mono- and triterpenes (see terpenes below) such as rosiridol and rosiridin, gallic acid and epicatechin tannins (see tannins below).

Rose root root is said to improve long-term memory. The drug has a supporting effect in stressful situations and increases mental and physical performance. Furthermore, antiphlogistic effects of the extract can be proven (Abidov M et al. 2000).

Based on clinical studies, the rose-root root is used to increase mental and physical performance. Further indications are symptoms of stress such as feelings of weakness and tiredness.

The daily dose of the drug is 0.2 g, which should be taken in the first half of the day. In addition, it is recommended that the drug be taken for at least 4 months.

Internal use: Insomnia. However, contact dermatitis may occur on contact with the fresh root.

No interactions with other medications were found.

e.g. Rhodiolae roseae radix capsules or drops - Vitango® film-coated tablets

^Vitango® film-coated tablets

Although rose-root has similarities to ginkgo preparations, it is not a substitute for them.

Not suitable for persons under 18 years of age. Do not use for more than 2 weeks without medical advice.

1. Abidov M et al. (2000) Extract of Rhodiola rosea radix reduces the level of C-reactive protein and
   creatinine kinase in the blood. Bull Exp Biol Med 138:63-64.
   Cayer C et al. (2013) Characterization of the anxiolytic activity of Nunavik Rhodiola rosea. Planta Med 79:1385-1391.
2. Hernández-Santana A et al. (2014) A Rhodiola rosea root extract protects skeletal muscle cells against chemically induced oxidative stress by modulating heat shock protein 70 (HSP70) expression. Phytother Res 28:623-628.
3. Mudge E et al. (2013) Purification of phenylalkanoids and monoterpene glycosides from Rhodiola rosea L. roots by high-speed counter-current chromatography. Phytochem Anal 24:129-134.
4. Nabavi SF et al. (2016) Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy. Phytother Res 30:532-539.
5. Panossian A et al. (2010) Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine 17:481-493.
6. Punja S et al. (2014) Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial. PLoS One 9:e108416.
7. Schilcher H (2016) In: Leitfaden Phytotherapie, Urban & Fischer Verlag Munich, p. 273 f.
8. https://arzneipflanzenlexikon.info/rosenwurz.php
9. https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-rhodiola-rosea-first-version_en.pdf
10. Wenigmann M. (2017) Phytotherapy medicinal drugs, phytopharmaceuticals, application. Urban & Fischer, pp. 182-183
11. Ivanova Stojcheva E et al. (2022) The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence. Molecules. 17;27(12):3902. doi: 10.3390/molecules27123902. PMID: 35745023; PMCID: PMC9228580.
12. https://www.bfr.bund.de/cm/350/risikobewertung-von-pflanzen-und-pflanzlichen-zubereitungen-ergaenzte-auflage.pdf