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Menthoxypropanediol
Synonym(s)
DefinitionThis section has been translated automatically.
Menthoxypropanediol is a synthetic derivative of menthol. The substance has a 2.0-2.5 times stronger cooling effect than menthol.
Pharmacodynamics (Effect)This section has been translated automatically.
Menthoxypropanediol is like the naturally occurring menthol a TRPM8 - agonist.
Spectrum of actionThis section has been translated automatically.
The family of cellular TRP ion channels is characterized by the fact that they have several transmembrane regions and are permeable to cations. One of these channels - TRPM8 (TRPM8 = transient receptor potential melastin 8, also called menthol receptor ) - is cooled by chemical coolants (including menthol itself as well as various other substances). menthol derivatives such as menthoxypropanediol). There is also evidence that activation of theTRPM8 receptor inhibits UV-induced inflammatory activities.
Furthermore, clinical studies in patients with atopic eczema have shown an antipruritic (and anti-eczematous) effect of menthoxypropanediol-containing topicals.
Undesirable effectsThis section has been translated automatically.
Contact allergies are described for the application of cosmetic external agents.
PreparationsThis section has been translated automatically.
Eucerin® AtopiControl Acute Care
LiteratureThis section has been translated automatically.
- Franken L et al (2013) Allergic contact dermatitis caused by menthoxypropanediol in a lip cosmetic. Contact dermatitis 69:377-378.
- Roggenkamp D et al (2016) Menthoxypropanediol inhibits nerve growth factor-induced nerve fibre sprouting in coculture models of sensory neurons and skin cells. Exp Dermatol 25:824-826.
- Angelova-Fischer I et al(2014) A randomized, investigator-blinded efficacy assessment study of stand-alone emollient use in mild to moderately severe atopic dermatitis flares. J Eur Acad Dermatol Venereol 28 Suppl 3: 9-15. https://www.ncbi.nlm.nih.gov/pubmed/24702445
- Ständer S et al(2016) Novel TRPM8 agonist cooling compound against chronic itch: results from a randomized, double-blind, controlled, pilot study in dry skin. J Eur Acad Dermatol Venereol doi: 10.1111/jdv.14041.