Eleutherococci radix

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 21.04.2024

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Synonym(s)

Eleutheroccus senticosus root; Ginseng Russian; Ginseng siberian; Radix Eleutherococci; Siberian ginseng; Taiga root

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DefinitionThis section has been translated automatically.

Eleutherococci radix, also known as taiga root or Siberian ginseng, is the dried, whole or cut underground part (rhizome and root) of the plant, which is used as a drug in herbal medicinal products to treat, among other things, reduced performance and concentration(adaptogen).

Quality defined in the European Pharmacopoeia (Ph. Eur.).

HMPC mon ograph: Traditional use: alleviation of symptoms of exhaustion: loss of strength and energy, tiredness, weakness
authorized: maintenance and activation of the body's own resistance, especially in cases of exceptional physical, emotional and mental stress

ESCOP monograph: decreasing mental and physical performance, weakness, exhaustion, fatigue, decreasing ability to concentrate, also during convalescence.
Commission e-monograph: tonic for strengthening and invigoration in case of fatigue and weakness, decreasing performance and ability to concentrate as well as during convalescence.

Empirical medicine: Activation of the body's own resistance to extraordinary physical, mental and psychological stress.

IngredientsThis section has been translated automatically.

Eleutherococci radix contains phenylpropane derivatives, coumarins, polysaccharides and lignans. The pharmacopoeia requires a minimum content of the oleanolic acid glycosides eleutheroside B and E of at least 0,08 %.

EffectsThis section has been translated automatically.

Eleutherococci radix improves cognitive and general performance and concentration, increases stress resistance, boosts the immune system; acts prophylactically against viral infections. For the specific effect of the oleanolic acid component of Eleutherococci radix see below. oleanolic acid.

Field of application/useThis section has been translated automatically.

Eleutherococci radix is used in cases of reduced performance and concentration (also in athletes), weakness and fatigue, burn-out syndrome and in convalescence after illness (monographs by ESCOP, Commission E).

DosageThis section has been translated automatically.

The daily dose of Eleutherococci radix is 2.0 to 3.0 g.

Eleutherococci radix is mostly taken in the form of tea infusions or aqueous-alcoholic extracts.
Due to the lack of long-term clinical studies, the duration of use should not exceed 3 months. A renewed intake is possible after a two-month break.

Undesirable effectsThis section has been translated automatically.

Insomnia, irritability, palpitations or headaches

ContraindicationThis section has been translated automatically.

Should not be taken if there are known problems with high blood pressure. Not for children under 12 years, no sufficient data for pregnancy and lactation.

InteractionsThis section has been translated automatically.

There are no known interactions with other substances.

Note(s)This section has been translated automatically.

Caution in patients with diabetes mellitus and hormone-dependent tumors!

LiteratureThis section has been translated automatically.

  1. Bhandari P et al. (2014) Oleanolic acid analogs as NO, TNF-α and IL-1β inhibitors: synthesis, biological evaluation and docking studies. Bioorg Med Chem Lett 24:4114-4119.
  2. Choi JK et al. (2013) Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model.Toxicol Appl Pharmacol 269:72-80.
  3. George VC et al (2012) Apoptosis-induced cell death due to oleanolic acid in HaCaT keratinocyte cells--a proof-of-principle approach for chemopreventive drug development. Asian Pac J Cancer Prev 13:2015-2020.
  4. Ghosh S et al. (2014) Oleanolic acid isolated from ethanolic extract of Phytolacca decandra induces apoptosis in A375 skin melanoma cells: drug-DNA interaction and signaling cascade. J Integr Med 12:102-114.
  5. Mabandla MV et al (2015) Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration. Brain Res 1622:64-71.
  6. Mu DW et al (2015) Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. Int J Clin Exp Pathol 8:13864-13870.
  7. Rui LX et al (2016) The dual induction of apoptosis and autophagy by SZC014, a synthetic oleanolic acid derivative, in gastric cancer cells via NF-κB pathway. Tumour Biol 37:5133-5144.
  8. Schilcher H (2016) In: Leitfaden Phytotherapie, Urban & Fischer Verlag Munich, pp. 307 f.
  9. Załuski D et al. (2012) Bioactive compounds and antioxidant, antileukemic and anti-MMPs activity of Eleutherococcus species cultivated in Poland. Nat Prod Commun 7:1483-1486.
  10. Zhu YY et al (2015) Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells. Mol Med Rep 12:5012-5018.
  11. https://arzneipflanzenlexikon.info/sibirischer-ginseng.php.
  12. https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-eleutherococcus-senticosus-rupr-et-maxim-maxim-radix_en.pdf
  13. Wenigmann M.(2017) Phytotherapy medicinal drugs phytopharmaceuticals application. Urban & Fischer: 5.108 Rock cinquefoil (Meliloti herba) pp 202-203.

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Last updated on: 21.04.2024