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Colchici semen

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.09.2023

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Synonym(s)

Autumn timeless seeds; semen colchici; Timeless seeds

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DefinitionThis section has been translated automatically.

Semen colchici, the official preparations of the seeds of autumn cro cus contains preparations of the dried and crushed seeds. Treatment with autumn crocus seeds can be done only if the preparations are adjusted to an exact amount of colchicine.

ESCOP mon ograph: no editing

HMPC monograph: no editing

Commission E-monograph: positive evaluation for auten gout attack; Familial Mediterranean fever.

IngredientsThis section has been translated automatically.

Efficacy determining ingredients are about 20 different colchicine alkaloids with the main alkaloid colchicine. Furthermore fatty oil, proteins, sugar.

EffectsThis section has been translated automatically.

According to the Commission E: antichemotactic, antiphlogistic, mitosis inhibiting. Popular in rheumatic diseases ; experimental in autoimmunological diseases, local in actinic keratoses.

Field of application/useThis section has been translated automatically.

Acute onset of gout, familial Mediterranean fever. Experimentally topical in actinic keratoses; furthermore in autoinflammatory syndromes like PAFA.

DosageThis section has been translated automatically.

In acute attacks of gout 1mg p.o. followed by repetitive doses (at 1-2 hourly intervals) of 0.5mg-1.0mg. A daily dose of 8.0mg must not be exceeded.

Undesirable effectsThis section has been translated automatically.

Diarrhoea, nausea, vomiting (see package insert of finished products)

ContraindicationThis section has been translated automatically.

Impaired kidney function, blood work. (e.g. anemia), known gastrointestinal diseases, reduced cardiovascular function, polymorbidity, liver disease, children, adolescents, pregnancy.

Trade namesThis section has been translated automatically.

Colchicum-Dispert® coated tablet

Note(s)This section has been translated automatically.

Colchicine is toxic. The lethal dose is about 20mg. Both drug and pure colchicine are prescription drugs.

LiteratureThis section has been translated automatically.

  1. Dustin P (1963. New aspects of the pharmacology of antimitotic agents. Pharmacol Rev15: 449-480.
  2. Faghihi G et al (2016) Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study. Adv Med doi: 10.1155/2016/5918393.
  3. Finkelstein Y et al(2010) Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila) 48: 407-414.
  4. Vanoni F et al (2016) PFAPA syndrome: a review on treatment and outcome. Pediatrics Rheumatol Online J 14:38.

Authors

Last updated on: 29.09.2023

Author: Prof. Dr. med. Peter Altmeyer