Boldo folium
Synonym(s)
DefinitionThis section has been translated automatically.
Boldo folium, also called boldo leaves, the leaves of the boldo shrub, is a drug used as an herbal medicine with biliary and digestive effects.
HMPC monograph: Traditional-use: dyspeptic complaints, mild gastrointestinal crampsESCOP monograph
: mild hepatobiliary dysfunction, mild digestive complaintsCommission
E monograph: mild, crampy gastrointestinal complaints; dyspeptic complaints.
IngredientsThis section has been translated automatically.
Boldo leaves contain 0.25 to 0.5 % isoquinoline alkaloids (mainly of the morphinan type), with boldo being the main alkaloid. Further ingredients are flavonoids and 2 to 3 % essential oil.
EffectsThis section has been translated automatically.
Besides a spasmolytic and choleretic effect, boldo leaves also have an antiphlogistic and cholecinetic effect. They also increase the secretion of gastric juice.
The spasmolytic effect is achieved by Boldin reducing the responsiveness of the vasodilator and vasoconstrictor nerve endings.
Field of application/useThis section has been translated automatically.
Boldo leaves are used for light, crampy gastrointestinal complaints and dyspeptic complaints with reduced bile production.
DosageThis section has been translated automatically.
The usual average daily dose is 3.0 g of the drug. The drug is administered in crushed form for infusions (e.g. tea infusions, 3 x / day) and other preparations (e.g. dry extracts up to 400mg 3x daily) for ingestion.
Undesirable effectsThis section has been translated automatically.
Undesirable effects are not known. Hypersensitivity reactions cannot be excluded.
ContraindicationThis section has been translated automatically.
In the presence of severe liver disease, obstruction of the bile ducts or pregnancy, it should not be taken. In the case of gallstones, the intake should only be made after consultation with a doctor.
Do not use on pregnant women or persons under 18 years of age,
LiteratureThis section has been translated automatically.
- Hošt'álková A et al.(2015) Alkaloids from Peumus boldus and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat Prod Commun 10:577-580.
- Petigny L et al. (2014) Simultaneous microwave extraction and separation of volatile and non-volatile organic compounds of boldo leaves. From lab to industrial scale. Int J Mol Sci 15:7183-7198.
- Piscaglia F et al. (2005) Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 40:236-239.
- Russo A et al. (2011) Boldo prevents UV light and nitric oxide-mediated plasmid DNA damage and reduces the expression of Hsp70 protein in melanoma cancer cells. J Pharm Pharmacol 63:1219-1229.
- Schilcher H (2016) Leitfaden Phytotherapie. Urban & Fischer Verlag Munich, p. 87 f.
- Vila R et al.(1999) Composition and antimicrobial activity of the essential oil of Peumus boldus leaves. Planta Med 65:178-179.
- Yu B et al.(2009) The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells. J Med Food 12:1074-1083.
- https://arzneipflanzenlexikon.info/boldostrauch.php.
- https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-peumus-boldus-molina-folium_en.pdf