Allantoin

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

All authors of this article

Last updated on: 25.09.2023

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DefinitionThis section has been translated automatically.

Keratolytic. Diureide of glyoxylic acid, which is formed from uric acid by the enzyme uricase. It is the end product of purine metabolism in most animals (not in humans). Allantoin is present in the plant kingdom in a few specimens, such as Symphytum offcinale (comfrey), bark of horse chestnut, wheat germ.

Allantoin is soluble in cold water up to 0.5%, in hot water up to 4%.

Pharmacodynamics (Effect)This section has been translated automatically.

Is converted into urea on the skin, has a skin-soothing, keratolytic and granulation-promoting effect, increases the skin's water-binding capacity.

The effect of fly maggots (fly maggots excrete allantoin) on infected wounds is based on allantoin action. This also applies to extracts from comfrey roots.

IndicationThis section has been translated automatically.

Acne vulgaris, psoriasis vulgaris, eczema, scars, wound treatment.

Standard concentrationThis section has been translated automatically.

0.2-5% in water absorbing ointments (absorption bases), hydrophilic ointments, hydrophobic creams (W/O emulsion ointments), hydrophilic creams (O/W emulsion ointments), hydrogels and powders.

PreparationsThis section has been translated automatically.

Contractubex, Lipo Cordes cream, La Roche-Posay Xerand hand cream O/W emulsion

Authors

Last updated on: 25.09.2023

Authors: Prof. Dr. med. Peter AltmeyerProf. Dr. med. Martina Bacharach-Buhles