Vancomycin
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
5–6 h
Spectrum of actionThis section has been translated automatically.
Clostridium spp., Corynebacterium diphtheriae, Enterococcus spp., Staph. aureus, coagulase-negative staphylococci, Streptococcus spp.
IndicationThis section has been translated automatically.
Severe infections caused by staphylococci, streptococci and enterococci with resistance to other antibiotics or penicillin allergy. Infections of foreign bodies (e.g. endoprostheses), endocarditis, osteomyelitis and pneumonia (in combination with rifampicin, fosfomycin or gentamicin).
Limited indicationThis section has been translated automatically.
Breastfeeding.
Dosage and method of useThis section has been translated automatically.
- Adults: 1-2 g/day in 2-4 ED each in 500 ml 5% glucose solution for at least 60 min. i.v.
- Children: 20-40 mg/kg bw/day
- infants and newborns: initial 15 mg/kg bw, maintenance dose during the first week of life 10 mg/kg every 12 hours, from the second week of life up to 1 month 10 mg/kg every 8 hours
Undesirable effectsThis section has been translated automatically.
Allergic reactions ( Red-Man-Syndrome)
Maculopapular exanthema
Erythema (exudative) multiforme
Often eosinophilia, interstitial nephritis, fever, hearing disorders. If infusion is too fast, thrombophlebitis in the area of the infusion site.
Notice! In case of reduced renal function accumulation: nephrotoxicity and ototoxicity!
S.a. under AER: AER is the acronym for Vancomycin-resistant Enterococci. Vancomycin-resistant Enterococci are primarily recruited from the increasing reservoir of E. faecium isolates. They are mostly resistant to all glycopeptides.
InteractionsThis section has been translated automatically.
Caution in combination with ototoxic drugs.
ContraindicationThis section has been translated automatically.
Pre-damage of the vestibular or cochlear apparatus, pregnancy.
PreparationsThis section has been translated automatically.
Vancomycin Lilly, Vancomycin-ratiopharm, Vancomycin Abbott
LiteratureThis section has been translated automatically.
- Niikura T et al (2007) Vancomycin-impregnated calcium phosphate cement for methicillin-resistant Staphylococcus aureus femoral osteomyelitis. Orthopedics 30: 320-321